Dopamine‐Based High‐Transparent Hydrogel as Bioadhesive for Sutureless Ocular Tissue Repair

Abstract Ocular injuries and their complications represent the most common causes of visual impairment. For ocular surgery, there is an unmet need for highly transparent bioadhesives with superior adhesion, biocompatibility, regenerative properties. Herein, a novel high‐transparent bioadhesive hydrogel composed gelatin methacryloyl (GelMA) dopamine methacrylamide (DMA) developed by in situ oxidative free‐radical polymerization. This overcomes fundamental weakness mussel‐inspired adhesive copolymers clinical practice combining multiple favorable properties, including high light transmission, mechanical strength, biocompatibility. DMA significantly enhances corneal epithelial cells proliferation, migration on GelMA, prevents accumulation reactive oxygen species (ROS) cells. In rabbit models conjunctiva transplantation, able to decrease inflammatory response fibrosis formation induced suture surgical trauma. addition, stromal defect model reveals that Gel/DMA could effectively seal defects, accelerates re‐epithelialization, promotes wound healing. Thus, given advantages bioactivity simple preparation, represents promising strategy suture‐free repair.